Stone tools and the linguistic capabilities of earlier hominids

The evolution of human manipulative abilities may be clearly linked to the evolution of speech motor control Both creativity and complexity in vocal and manipulative gestures may be closely linked to a single dimension of brain evolution — the evolution of absolute brain size. Inferring the linguistic capabilities of earlier hominids from their lithic artefacts, however, required us to take account of domain-specific constraints on manipulative skill In this article we report on a pilot flint-knapping experiment designed to identify such constraints ‘in action’

Unitary groups over local rings

Structural properties of unitary groups over local, not necessarily commutative, rings are developed, with applications to the computation of the orders of these groups (when finite) and to the degrees of the irreducible constituents of the Weil representation of a unitary group associated to a ramified extension of finite local rings

Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis.

During Drosophila development, the formin actin nucleator Cappuccino (Capu) helps build a cytoplasmic actin mesh throughout the oocyte. Loss of Capu leads to female sterility, presumably because polarity determinants fail to localize properly in the absence of the mesh. To gain deeper insight into how Capu builds this actin mesh, we systematically characterized seven capu alleles, which have missense mutations in Capu's formin homology 2 (FH2) domain. We report that all seven alleles have deleterious effects on fly fertility and the actin mesh in vivo but have strikingly different effects on Capu's biochemical activity in vitro. Using a combination of bulk and single- filament actin-assembly assays, we find that the alleles differentially affect Capu's ability to nucleate and processively elongate actin filaments. We also identify a unique "loop" in the lasso region of Capu's FH2 domain. Removing this loop enhances Capu's nucleation, elongation, and F-actin-bundling activities in vitro. Together our results on the loop and the seven missense mutations provides mechanistic insight into formin function in general and Capu's role in the Drosophila oocyte in particular

Characterization of Power-to-Phase Conversion in High-Speed P-I-N Photodiodes

Fluctuations of the optical power incident on a photodiode can be converted into phase fluctuations of the resulting electronic signal due to nonlinear saturation in the semiconductor. This impacts overall timing stability (phase noise) of microwave signals generated from a photodetected optical pulse train. In this paper, we describe and utilize techniques to characterize this conversion of amplitude noise to phase noise for several high-speed (>10 GHz) InGaAs P-I-N photodiodes operated at 900 nm. We focus on the impact of this effect on the photonic generation of low phase noise 10 GHz microwave signals and show that a combination of low laser amplitude noise, appropriate photodiode design, and optimum average photocurrent is required to achieve phase noise at or below -100 dBc/Hz at 1 Hz offset a 10 GHz carrier. In some photodiodes we find specific photocurrents where the power-to-phase conversion factor is observed to go to zero

The functionalization of carbon nanosheets

Carbon nanosheets are a novel two-dimensional nanostructure made up of 2-20 graphene atomic planes oriented with their in-plane axis perpendicular to the growth substrate. Previous efforts in developing nanosheet technology have focused on the characterization of the system and their development as an electron source due to the high atomic enhancement factor (beta) and low turn on field. Further investigation of nanosheets as high surface area electrodes revealed poor wetting by polymeric material and extreme hydrophobic behavior.;Because nanosheet technology has promise as a high surface area electrode material, this thesis research has focused on three areas of interest: the enhancement of nanosheets through chemical modification, the incorporation of the nanosheets into a polymeric composite and the delivery of a proof of concept measurement. We have successfully introduced defects into the graphene lattice of the nanosheet system via an acid treatment. Inspection of these defects by x-ray absorption near-edge spectroscopy (XANES) shows the introduction of two features in the spectra assigned to C=O pi* and C-O sigma* transitions. Thermal desorption spectroscopy (TDS) was used to identify the oxygen containing groups created during the functionalization as carboxylic and hydroxyl functional groups. These groups were identified through the combination of carboxylic, hydroxyl, anhydride and lactone peaks in the CO2, CO and H 2O TDS spectra. Deconvolution of the TDS spectra using 1st and 2nd order Polanyi-Wigner equations enables the calculation of desorption energy values for individual features and for the estimation of the number of atoms desorbing from the surface during a particular event. Identification of the exact nature of the functional groups was attempted through high resolution x-ray photoelectron spectroscopy (XPS) of the C(1s) and O(1s) peaks. Though the pairing of sub-peaks with specific functionalities of the system was not possible due to the complexities of the spectra, the trends observed in the data support the data gathered via the XANES and TDS experiments.;Also, a procedure for the classification of defect density and exact functionality was outlined. Deconvolution of the TDS spectra using 1 st and 2nd order Polanyi-Wigner equations enabled the calculation of desorption energy values for individual features and for the estimation of the number of atoms desorbing from the surface during a particular event. This information along with the changing sub-peak areas from dedicated and calibrated XPS system would allow for not only a more accurate estimation of defect density, but also for the identification of sub-peaks in the C(1s) and O(1s) spectra.;Finally, photoluminescence measurements of poly[2-methoxy-5-(2\u27-ethyl-hexyloxy)-1,4-phenylene vinylene] (MEH-PPV) and MEH-PPV/nanosheet systems showed a quenching of three orders of magnitude for the MEH-PPV/nanosheet system suggesting that nanosheets are a viable option for excition separation in organic photovoltaics

Presentation modality influences behavioral measures of alerting, orienting, and executive control

The Attention Network Test (ANT) uses visual stimuli to separately assess the attentional skills of alerting (improved performance following a warning cue), spatial orienting (an additional benefit when the warning cue also cues target location), and executive control (impaired performance when a target stimulus contains conflicting information). This study contrasted performance on auditory and visual versions of the ANT to determine whether the measures it obtains are influenced by presentation modality. Forty healthy volunteers completed both auditory and visual tests. Reaction-time measures of executive control were of a similar magnitude and significantly correlated, suggesting that executive control might be a supramodal resource. Measures of alerting were also comparable across tasks. In contrast, spatial-orienting benefits were obtained only in the visual task. Auditory spatial cues did not improve response times to auditory targets presented at the cued location. The different spatial-orienting measures could reflect either separate orienting resources for each perceptual modality, or an interaction between a supramodal orienting resource and modality-specific perceptual processing

Neuronal Diseases: Small Heat Shock Proteins Calm Your Nerves

AbstractMutations in HSPB1 and HSPB8, members of the small heat shock protein family, have recently been shown to cause some distal motor neuropathies. Their function in motor neurones is now under scrutiny